Journal: EJNMMI Research

Article Title: Using advanced cell models for targeted radionuclide therapy evaluation: increased efficacy in 3D versus 2D

doi: 10.1186/s13550-026-01393-0

Figure Lengend Snippet: Viability of PC3-PIP cells cultured as bio-spheroids or in 2D setting measured 6 days after (a) incubation with several activity concentrations of PSMA-TRT (n = 4) or (b) exposure to varying doses of EBRT (n = 3). Data are normalized to untreated controls. Representative images of untreated, PSMA-TRT-treated and EBRT-treated bio-spheroids are shown. All microscopic images have the same scale. 2D = two-dimensional , PSMA-TRT = prostate-specific membrane antigen targeted radionuclide therapy , EBRT = external beam radiation therapy , Gy = gray

Article Snippet: Endogenously prostate-specific membrane antigen (PSMA)-expressing LNCaP cells (American Type Culture Collection) and PSMA-transduced PC3-PIP cells (kindly provided by prof. Anna Orlova, Uppsala University, Sweden) were used.

Techniques: Cell Culture, Incubation, Activity Assay, Membrane

Journal: Tomography

Article Title: Optimizing Microbubble Reduction to Facilitate IVUS Guidance During Endovascular Radiofrequency Wire Procedures

doi: 10.3390/tomography12040048

Figure Lengend Snippet: IVUS images of the L12-3 probe application method with selected ROI (blue-green box) for all trials. The L12-3 probe was secured to the top of the model tissue before initial imaging. Following RF puncture, US from the L12-3 probe was applied for 10 s before reimaging on IVUS. ( a ) Trial 1 images-before RF puncture (left), after RF puncture (middle), and after L12-3 application (right). ( b ) Trial 2 images before RF puncture (left), after RF puncture (middle), and after L12-3 application (right). ( c ) Trial 3 images before RF puncture (left), after RF puncture (middle), and after L12-3 application (right).

Article Snippet: 5 , Philips L12-3 Broadband Linear Array Transducer, Philips Ultrasound, Inc., Bothell, WA, USA , - Disrupting transducer connected to EPIQ 7G system - MI: 1.2, Frequency: 3 MHz, Tx power: 100%, Mode: B.

Techniques: Imaging

Journal: Tomography

Article Title: Optimizing Microbubble Reduction to Facilitate IVUS Guidance During Endovascular Radiofrequency Wire Procedures

doi: 10.3390/tomography12040048

Figure Lengend Snippet: ( a ) Scatterplot of average ROI brightness at each experimental stage for the baseline, IVUS MI increase, VF10-5 application, and L12-3 application average. Note: the baseline data point for ‘After US’ represents after a waiting period of two minutes. ( b ) Bar graph of calculated % reduction of RF puncture obstruction for the baseline, IVUS MI increase, VF10-5 application, and L12-3 application. A SEM error bar is included for the L12-3 average. See for raw data and calculated values.

Article Snippet: 5 , Philips L12-3 Broadband Linear Array Transducer, Philips Ultrasound, Inc., Bothell, WA, USA , - Disrupting transducer connected to EPIQ 7G system - MI: 1.2, Frequency: 3 MHz, Tx power: 100%, Mode: B.

Techniques: